RPL3L

Across TCGA patient cohorts, RPL3L mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL3L-associated genes across cancer lineages are p38-MAPK_pT180_Y182, eEF2, and EGFR_pY1068. Each is linked with RPL3L in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL3L-to-partner and partner-to-RPL3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by RPL3L-low versus RPL3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL3L→partner) and Y-score (partner→RPL3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.537	-2.999	.006	.035	3	2
UCEC	eEF2 →	+0.404	+3.169	.009	.018	3	1
UCEC	EGFR_pY1068 →	-0.287	-2.807	.008	.003	3	1
UCEC	Fibronectin →	-0.306	-2.990	.033	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-2.102	.004	.019	3	1
UCEC	Ku80 →	+0.247	+2.331	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

p38-MAPK_pT180_Y182 by RPL3L expression — UCEC

Explore this box plot interactively →