Across TCGA pan-cancer cohorts, RPL39P14 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL39P14’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPL39P14 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL39P14 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and LIHC are the cancer types where RPL39P14 tumor–normal differential expression is most reproducible.