Across TCGA pan-cancer cohorts, RPL38P4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RPL38P4’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL38P4 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL38P4 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where RPL38P4 tumor–normal differential expression is most reproducible.