Across TCGA pan-cancer cohorts, RPL38P3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPL38P3’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL38P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL38P3 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.
COAD, LUAD, and LIHC are the cancer types where RPL38P3 tumor–normal differential expression is most reproducible.