Across TCGA pan-cancer cohorts, RPL36AP53 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPL36AP53’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RPL36AP53 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL36AP53 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

KIRP, LUSC, and HNSC are the cancer types where RPL36AP53 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL36AP53 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−0.165	<.001	6	view →
LUSC	All	II,III,IV	+0.071	.008	3	view →
HNSC	Male	III,IV	+0.061	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RPL36AP53 RNA expression & survival · all RPL36AP53 data types