Across TCGA pan-cancer cohorts, RPL36AP10 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPL36AP10’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where RPL36AP10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL36AP10 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
ESCA, BRCA, and LUSC are the cancer types where RPL36AP10 tumor–normal differential expression is most reproducible.