RPL36AL

Across TCGA pan-cancer cohorts, RPL36AL RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RPL36AL data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPL36AL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPL36AL expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

HNSC, KICH, and ACC are the cancer types where RPL36AL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.485	0.686	<.001	98	view →
KICH	DFS	Median	II,III,IV	0.672	1.000	.001	76	view →
ACC	DFS	Median	All	0.264	0.642	<.001	70	view →
UCS	OS	Median	III,IV	0.339	0.789	<.001	64	view →
KIRC	DFS	Median	All	0.709	0.550	<.001	55	view →
LUAD	DFS	Median	II,III,IV	0.442	0.641	<.001	55	view →
BRCA	OS	Quartile	III,IV	0.903	0.703	.003	49	view →
LGG	DFS	Median	All	0.798	0.674	<.001	47	view →
THCA	DFS	Median	All	0.912	0.765	.005	33	view →
UCEC	OS	Tertile	II,III,IV	0.698	0.550	.018	20	view →
READ	OS	Tertile	III,IV	0.225	0.654	.005	19	view →
THYM	OS	Median	II,III,IV	1.000	0.920	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RPL36AL–HNSC (DFS)

Open the HNSC breakdown →