Across TCGA pan-cancer cohorts, RPL35AP31 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL35AP31’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL35AP31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL35AP31 is over-expressed in tumor.
COAD and BRCA are the cancer types where RPL35AP31 tumor–normal differential expression is most reproducible.