Across TCGA pan-cancer cohorts, RPL35AP30 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL35AP30’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL35AP30 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL35AP30 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
COAD and KICH are the cancer types where RPL35AP30 tumor–normal differential expression is most reproducible.