Q-omics provides the consensus-scored RPL35AP21 profile across patient tissues and cancer cell-line models. RPL35AP21 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RPL35AP21 is differentially expressed in 8, with the highest sampling consensus in COAD. Additionally, RPL35AP21 RNA expression shows 8,183 significant gene co-expression associations, with the highest sampling consensus in READ. Together, these results highlight KIRC, COAD, and READ as cancer lineages where RPL35AP21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RPL35AP21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RPL35AP21 survival associations across molecular data types. RPL35AP21 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RPL35AP21 RNA expression–survival associations across cancer types. High RPL35AP21 expression shows unfavorable associations in KIRC, DLBC, ACC, UVM and KICH, but favorable associations in CESC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .005). Together, the overview and detailed table identify KIRC as the clearest survival context for RPL35AP21 RNA expression.
This table summarizes RPL35AP21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for RPL35AP21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RPL35AP21 shows lower tumor expression in PAAD and BRCA and higher tumor expression in COAD, ESCA, STAD and KICH. The COAD box plot shows higher RPL35AP21 RNA expression in tumor versus normal tissue (log2 FC = +1.651, t-test p < 0.001).
This table shows molecular features associated with RPL35AP21 in patient tissues and cancer cell lines. In patient samples, RPL35AP21 shows the broadest associations at the RNA and protein expression levels, with READ recurring as the lineage with the largest associated feature set.
