RPL35A

Across TCGA patient cohorts, RPL35A mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL35A-associated genes across cancer lineages are MIR5191, SNORA74C-1, and OR4K15. Each is linked with RPL35A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL35A-to-partner and partner-to-RPL35A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5191 grouped by RPL35A-low versus RPL35A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL35A→partner) and Y-score (partner→RPL35A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5191 →	+0.550	+5.226	<.001	.003	3	1
UCEC	SNORA74C-1 →	+0.637	+4.256	<.001	.008	3	1
UCEC	OR4K15 →	+0.078	+4.937	.001	.005	3	1
UCEC	OR5B2 →	+0.101	+4.551	.001	.009	3	1
UCEC	OR2T1 →	+0.098	+4.937	<.001	.005	3	1
UCEC	RNA5SP131 →	+0.503	+4.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MIR5191 by RPL35A expression — UCEC

Explore this box plot interactively →