RPL34

Across TCGA pan-cancer cohorts, RPL34 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RPL34’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RPL34 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RPL34 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where RPL34 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL34 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.801	<.001	12	view →
CCRCC	Female	All	+0.767	<.001	11	view →
LSCC	All	All	+0.263	<.001	7	view →
LUAD	Male	All	+0.336	<.001	6	view →
HNSC	All	All	+0.271	<.001	6	view →
PDAC	Female	All	−0.403	.023	3	view →
OV	All	All	+0.779	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RPL34–COAD

Open the COAD breakdown →