Across TCGA pan-cancer cohorts, RPL31P54 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL31P54’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RPL31P54 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL31P54 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.
THCA and LUAD are the cancer types where RPL31P54 tumor–normal differential expression is most reproducible.