RPL3

Across TCGA patient cohorts, RPL3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL3-associated genes across cancer lineages are MEK1, Notch1, and p38-MAPK_pT180_Y182. Each is linked with RPL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPL3-to-partner and partner-to-RPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RPL3-low versus RPL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL3→partner) and Y-score (partner→RPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.543	+2.906	<.001	.001	3	2
UCEC	Notch1 →	+0.221	+3.469	<.001	.002	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.565	-2.000	.003	.030	3	2
UCEC	PDCD4 →	-0.712	-3.321	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.232	-2.222	.029	.011	3	1
UCEC	eIF4G →	+0.305	+3.169	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by RPL3 expression — UCEC

Explore this box plot interactively →