Across TCGA pan-cancer cohorts, RPL26P20 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPL26P20’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPL26P20 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL26P20 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.
LUSC, KICH, and COAD are the cancer types where RPL26P20 tumor–normal differential expression is most reproducible.