Across TCGA pan-cancer cohorts, RPL23AP76 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RPL23AP76’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL23AP76 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL23AP76 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where RPL23AP76 tumor–normal differential expression is most reproducible.