RPL23AP66

Across TCGA pan-cancer cohorts, RPL23AP66 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RPL23AP66 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPL23AP66 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RPL23AP66 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, UVM, and UCS are the cancer types where RPL23AP66 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.768	0.618	<.001	129	view →
UVM	OS	Median	All	0.745	1.000	.005	48	view →
UCS	DFS	Median	All	0.258	0.575	.003	38	view →
BLCA	OS	Tertile	All	0.668	0.558	.012	37	view →
CHOL	DFS	Median	II,III,IV	0.134	0.575	.005	22	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	19	view →
LUAD	DFS	Median	All	0.573	0.720	.006	17	view →
LGG	DFS	Median	All	0.764	0.881	.003	12	view →
ESCA	OS	Tertile	III,IV	0.654	0.385	.012	9	view →
TGCT	DFS	Median	II,III,IV	0.772	1.000	.041	8	view →
ACC	DFS	Median	All	0.687	0.498	.030	7	view →
PAAD	OS	Quartile	II,III,IV	0.554	0.297	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RPL23AP66–HNSC (OS)

Open the HNSC breakdown →