Across TCGA pan-cancer cohorts, RPL23AP6 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPL23AP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL23AP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL23AP6 is over-expressed in tumor.

KIRC, LIHC, and COAD are the cancer types where RPL23AP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23AP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.048	<.001	7	view →
LIHC	All	All	+0.061	.001	4	view →
COAD	All	All	+0.078	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RPL23AP6 RNA expression & survival · all RPL23AP6 data types