RPL23AP54

Across TCGA pan-cancer cohorts, RPL23AP54 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated RPL23AP54 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPL23AP54 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RPL23AP54 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

HNSC, SARC, and KIRC are the cancer types where RPL23AP54 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.841	0.326	.001	90	view →
SARC	DFS	Tertile	All	0.197	0.624	<.001	45	view →
KIRC	DFS	Tertile	IV	0.106	0.640	<.001	36	view →
UVM	DFS	Tertile	All	0.071	0.746	<.001	27	view →
THYM	DFS	Tertile	All	0.579	0.920	.023	9	view →
STAD	DFS	Quartile	All	0.216	0.400	.034	3	view →
ESCA	OS	Tertile	All	0.794	0.654	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RPL23AP54–HNSC (OS)

Open the HNSC breakdown →