Across TCGA pan-cancer cohorts, RPL23AP53 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RPL23AP53’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RPL23AP53 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL23AP53 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.
LIHC, LUSC, and KIRP are the cancer types where RPL23AP53 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23AP53 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.