RPL23AP49

Across TCGA pan-cancer cohorts, RPL23AP49 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RPL23AP49’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RPL23AP49 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL23AP49 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and STAD are the cancer types where RPL23AP49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23AP49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−2.297	<.001	10	view →
HNSC	Male	II,III,IV	−0.848	<.001	10	view →
STAD	All	II,III,IV	−0.504	.002	7	view →
BRCA	All	III,IV	−1.893	<.001	6	view →
COAD	Female	III,IV	−1.042	.002	6	view →
LUSC	Male	II,III,IV	−0.695	<.001	6	view →
UCEC	All	All	−1.043	.001	4	view →
THCA	Male	IV	−1.829	.003	3	view →
PRAD	All	All	−0.853	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RPL23AP49–KICH

Open the KICH breakdown →