Across TCGA pan-cancer cohorts, RPL23AP4 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPL23AP4’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RPL23AP4 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL23AP4 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA, THCA, and LUAD are the cancer types where RPL23AP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23AP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	IV	−0.229	.001	2	view →
THCA	Male	All	−0.058	.028	1	view →
LUAD	All	II,III,IV	−0.029	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RPL23AP4 RNA expression & survival · all RPL23AP4 data types