Across TCGA pan-cancer cohorts, RPL23AP39 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL23AP39’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RPL23AP39 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL23AP39 is over-expressed in tumor.
LUAD and THCA are the cancer types where RPL23AP39 tumor–normal differential expression is most reproducible.