Across TCGA patient cohorts, RPL23A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL23A-associated genes across cancer lineages are FoxM1, Ku80, and MEK1. Each is linked with RPL23A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL23A-to-partner and partner-to-RPL23A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL23A→partner) and Y-score (partner→RPL23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.335	+3.009	.009	.019	3	1
UCEC	Ku80 →	+0.298	+2.335	.011	.020	3	1
UCEC	MEK1 →	+0.538	+3.169	.003	.018	3	1
UCEC	Notch1 →	+0.255	+3.009	<.001	.019	3	1
UCEC	p90 RSK_pT359_S363 →	-0.255	-2.321	.011	.035	3	1
UCEC	PCNA →	+0.291	+2.321	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

RPL23A survival (RNA) · tumor vs normal (RNA) · all RPL23A data types