RPL22P19

Across TCGA patient cohorts, RPL22P19 mutation is significantly associated with the RNA expression of many other genes, with 2,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL22P19-associated genes across cancer lineages are PPIL2, CRYBB2P1, and CCDC134. Each is linked with RPL22P19 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL22P19-to-partner and partner-to-RPL22P19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIL2 grouped by RPL22P19-low versus RPL22P19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22P19→partner) and Y-score (partner→RPL22P19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPIL2 →	+0.451	+3.337	.001	.005	3	1
UCEC	CRYBB2P1 →	+0.564	+3.385	.002	.004	3	1
UCEC	CCDC134 →	+0.624	+2.721	.001	.003	3	1
UCEC	DDX17 →	+0.489	+3.818	.003	<.001	3	1
UCEC	SBF1 →	+0.753	+3.483	<.001	.002	3	1
UCEC	PACSIN2 →	+0.711	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,158 associations by consensus.

PPIL2 by RPL22P19 expression — UCEC

Explore this box plot interactively →