RPL22L1

Across TCGA cell cohorts, RPL22L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,366 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPL22L1-associated GO terms across cancer lineages are Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, Negative regulation of autophagy, and Regulation of tumor necrosis factor-mediated signaling pathway. Each is linked with RPL22L1 in more than 11 cancer types. Because this analysis shows association rather than direction, both RPL22L1-to-partner and partner-to-RPL22L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway grouped by RPL22L1-low versus RPL22L1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22L1→partner) and Y-score (partner→RPL22L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	-0.070	-1.399	.007	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	-0.075	-1.223	<.001	.002	3	11
PANCREAS	Regulation of tumor necrosis factor-mediated signaling pathway →	-0.081	-1.121	.001	.009	3	10
UPPER_AERODIGESTIVE_TRACT	tRNA 3'-terminal CCA addition →	+0.122	+1.071	.003	.004	3	10
UPPER_AERODIGESTIVE_TRACT	Mitochondrial gene expression →	+0.082	+1.479	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of type 2 mitophagy →	-0.121	-1.119	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,366 associations by consensus.

Negative regulation of cytoplasmic pattern recognition receptor signaling pathway by RPL22L1 expression — KIDNEY

Explore this box plot interactively →