RPL22

Across TCGA patient cohorts, RPL22 mutation is significantly associated with the RNA expression of many other genes, with 561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL22-associated genes across cancer lineages are RNU4-72P, RPL23AP50, and AQP7P3. Each is linked with RPL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL22-to-partner and partner-to-RPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-72P grouped by RPL22-low versus RPL22-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22→partner) and Y-score (partner→RPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4-72P →	+0.324	+5.290	<.001	<.001	3	1
SKCM	RPL23AP50 →	+0.133	+3.819	.001	.009	3	1
UCEC	AQP7P3 →	+0.051	+4.167	<.001	<.001	3	1
UCEC	LINC01943 →	+0.694	+3.354	<.001	.005	3	1
UCEC	ESS2 →	+0.439	+3.332	.001	.005	3	1
UCEC	PHF5A →	+0.570	+3.226	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 561 associations by consensus.

RNU4-72P by RPL22 expression — SKCM

Explore this box plot interactively →