RPL22

Across TCGA cell cohorts, RPL22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,213 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RPL22-associated GO terms across cancer lineages are Regulation of telomerase RNA localization to Cajal body, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with RPL22 in more than 11 cancer types. Because this analysis shows association rather than direction, both RPL22-to-partner and partner-to-RPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomerase RNA localization to Cajal body grouped by RPL22-low versus RPL22-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22→partner) and Y-score (partner→RPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.104	+0.965	<.001	<.001	3	12
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.134	+0.832	<.001	<.001	3	11
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.147	+1.153	<.001	<.001	3	10
BONE	Negative regulation of mRNA processing →	+0.142	+1.153	<.001	<.001	3	10
BONE	Negative regulation of RNA splicing →	+0.140	+1.200	<.001	<.001	3	10
BONE	Metanephric proximal tubule development →	+0.318	+0.930	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,213 associations by consensus.

Regulation of telomerase RNA localization to Cajal body by RPL22 expression — BONE

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