RPL22

Across TCGA cell cohorts, RPL22 mutation is significantly associated with the RNA expression of many other genes, with 2,816 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPL22-associated genes across cancer lineages are ULBP2, MSTN, and ZIC5. Each is linked with RPL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL22-to-partner and partner-to-RPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ULBP2 grouped by RPL22-low versus RPL22-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22→partner) and Y-score (partner→RPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ULBP2 →	+1.324	+3.257	<.001	.005	3	2
BLOOD_Leukemia	MSTN →	+0.289	+2.383	<.001	.005	3	2
BLOOD_Leukemia	ZIC5 →	+0.486	+2.841	<.001	.002	3	2
BLOOD_Leukemia	GPR180 →	+0.552	+3.489	.004	.001	3	2
BLOOD_Leukemia	RAB28 →	+0.598	+3.489	.002	.001	3	2
BLOOD_Leukemia	FLYWCH2 →	+0.474	+3.489	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,816 associations by consensus.

ULBP2 by RPL22 expression — BLOOD_Leukemia

Explore this box plot interactively →