RPL22

Across TCGA cell cohorts, RPL22 mutation is significantly associated with the mutation status of many other genes, with 7,196 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPL22-associated genes across cancer lineages are TCF20, GLI2, and IPO11. Each is linked with RPL22 in more than 4 cancer types. Because this analysis shows association rather than direction, both RPL22-to-partner and partner-to-RPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF20 grouped by RPL22-low versus RPL22-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22→partner) and Y-score (partner→RPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TCF20 →	+3.345	+3.882	.001	.001	1	5
STOMACH	GLI2 →	+3.115	+3.440	.003	.003	1	5
BLOOD_Lymphoma	IPO11 →	+5.584	+5.014	.003	.003	1	5
STOMACH	DOCK3 →	+3.700	+3.700	.001	.001	1	5
STOMACH	MYRIP →	+4.285	+3.357	.005	.005	1	5
OVARY	DDX59 →	+4.667	+5.421	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,196 associations by consensus.

TCF20 by RPL22 expression — OVARY

Explore this box plot interactively →