Across TCGA pan-cancer cohorts, RPL21P91 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RPL21P91’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where RPL21P91 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL21P91 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
PAAD are the cancer types where RPL21P91 tumor–normal differential expression is most reproducible.