Across TCGA pan-cancer cohorts, RPL21P9 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL21P9’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPL21P9 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL21P9 is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.
LUSC and KIRC are the cancer types where RPL21P9 tumor–normal differential expression is most reproducible.