RPL21P42

Across TCGA pan-cancer cohorts, RPL21P42 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RPL21P42’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPL21P42 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL21P42 is over-expressed in tumor, although a few such as LUSC and STAD show the opposite, repressed pattern.

LUSC, COAD, and STAD are the cancer types where RPL21P42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL21P42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−0.355	<.001	6	view →
COAD	All	All	+0.238	.003	6	view →
STAD	Male	All	−0.134	.035	3	view →
UCEC	All	All	−0.184	.017	2	view →
LIHC	Male	III,IV	+0.071	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RPL21P42–LUSC

Open the LUSC breakdown →