RPL21P23

Across TCGA pan-cancer cohorts, RPL21P23 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RPL21P23 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPL21P23 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RPL21P23 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, ACC, and SKCM are the cancer types where RPL21P23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.620	0.314	.001	97	view →
ACC	OS	Tertile	All	0.275	0.766	<.001	54	view →
SKCM	DFS	Tertile	II,III,IV	0.167	0.346	.004	45	view →
PAAD	DFS	Quartile	All	0.150	0.330	.002	44	view →
KIRP	DFS	Quartile	II,III,IV	0.152	0.640	.002	44	view →
COAD	OS	Tertile	All	0.882	0.776	.017	21	view →
UVM	OS	Tertile	All	0.248	0.769	.007	18	view →
CESC	OS	Quartile	IV	0.956	0.431	.032	18	view →
BLCA	DFS	Quartile	IV	0.218	0.497	.005	12	view →
READ	OS	Tertile	IV	0.077	1.000	.014	12	view →
CHOL	DFS	Tertile	IV	0.082	0.753	.008	9	view →
LIHC	OS	Median	III,IV	0.773	0.564	.016	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

RPL21P23–HNSC (OS)

Open the HNSC breakdown →