Across TCGA pan-cancer cohorts, RPL21P2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RPL21P2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL21P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL21P2 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.
COAD, LUSC, and THCA are the cancer types where RPL21P2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL21P2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.