Across TCGA pan-cancer cohorts, RPL21P133 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL21P133’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where RPL21P133 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL21P133 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.
UCEC and LUAD are the cancer types where RPL21P133 tumor–normal differential expression is most reproducible.