Across TCGA pan-cancer cohorts, RPL21P104 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL21P104’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RPL21P104 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL21P104 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
LUAD and KIRC are the cancer types where RPL21P104 tumor–normal differential expression is most reproducible.