Across TCGA pan-cancer cohorts, RPL18AP15 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RPL18AP15’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPL18AP15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL18AP15 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
COAD, LIHC, and KIRC are the cancer types where RPL18AP15 tumor–normal differential expression is most reproducible.