Across TCGA pan-cancer cohorts, RPL17P45 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL17P45’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RPL17P45 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL17P45 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where RPL17P45 tumor–normal differential expression is most reproducible.