Across TCGA pan-cancer cohorts, RPL17P3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL17P3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RPL17P3 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL17P3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and LUAD are the cancer types where RPL17P3 tumor–normal differential expression is most reproducible.