Across TCGA pan-cancer cohorts, RPL15P4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RPL15P4’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RPL15P4 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL15P4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where RPL15P4 tumor–normal differential expression is most reproducible.