RPL15

Across TCGA patient cohorts, RPL15 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL15-associated genes across cancer lineages are ERK2, FoxM1, and RAD51. Each is linked with RPL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL15-to-partner and partner-to-RPL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RPL15-low versus RPL15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL15→partner) and Y-score (partner→RPL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.225	+2.321	.019	.035	3	1
UCEC	FoxM1 →	+0.331	+3.459	.010	.005	3	1
UCEC	RAD51 →	+0.185	+2.321	.008	.035	3	1
UCEC	VHL →	-1.450	-3.169	<.001	.019	3	1
UCEC	Cyclin-B1 →	+0.698	+3.459	.013	.005	2	1
UCEC	JNK2 →	+0.318	+2.321	.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by RPL15 expression — UCEC

Explore this box plot interactively →