RPL13A

Across TCGA patient cohorts, RPL13A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL13A-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with RPL13A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL13A-to-partner and partner-to-RPL13A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RPL13A-low versus RPL13A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL13A→partner) and Y-score (partner→RPL13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.409	+2.502	.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.686	+1.700	.001	.040	3	2
UCEC	EGFR_pY1068 →	-0.267	-2.807	.003	<.001	3	1
UCEC	eIF4E →	+0.251	+3.820	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.162	-2.222	<.001	.010	3	1
UCEC	ERK2 →	+0.188	+1.807	.006	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ASNS by RPL13A expression — UCEC

Explore this box plot interactively →