Across TCGA patient cohorts, RPL12 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL12-associated genes across cancer lineages are EGFR_pY1173, p27_pT198, and p38-MAPK_pT180_Y182. Each is linked with RPL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL12-to-partner and partner-to-RPL12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL12→partner) and Y-score (partner→RPL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.116	+3.026	.012	.019	3	1
UCEC	p27_pT198 →	+0.135	+3.000	.029	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.596	-2.986	.022	.037	3	1
UCEC	PCNA →	+0.491	+3.000	<.001	.037	3	1
UCEC	PKC-delta_pS664 →	-0.188	-2.999	.006	.035	3	1
UCEC	AR →	-0.453	-3.000	.035	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

RPL12 survival (RNA) · tumor vs normal (RNA) · all RPL12 data types