RPL11

Across TCGA patient cohorts, RPL11 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL11-associated genes across cancer lineages are p27, mTOR, and Notch1. Each is linked with RPL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL11-to-partner and partner-to-RPL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27 grouped by RPL11-low versus RPL11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL11→partner) and Y-score (partner→RPL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p27 →	+0.277	+3.000	.007	.036	3	1
UCEC	mTOR →	-0.277	-3.459	<.001	.005	3	1
UCEC	Notch1 →	+0.217	+3.179	.002	.010	3	1
UCEC	4E-BP1_pS65 →	-0.194	-2.308	.048	.036	3	1
UCEC	Bid →	-0.120	-2.321	.046	.035	3	1
UCEC	Caspase-8 →	-0.290	-3.143	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p27 by RPL11 expression — SKCM

Explore this box plot interactively →