RPL10

Across TCGA patient cohorts, RPL10 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL10-associated genes across cancer lineages are MEK1, PCNA, and Shc_pY317. Each is linked with RPL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL10-to-partner and partner-to-RPL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RPL10-low versus RPL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL10→partner) and Y-score (partner→RPL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.465	+2.906	<.001	.001	3	2
UCEC	PCNA →	+0.358	+2.736	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.137	-1.807	.014	.025	3	2
UCEC	VEGFR2 →	+0.266	+1.874	.014	.049	3	2
UCEC	Bap1-c-4 →	+0.163	+1.861	.043	.005	3	2
UCEC	Chk2_pT68 →	-0.149	-2.312	.029	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

MEK1 by RPL10 expression — UCEC

Explore this box plot interactively →