RPIA

Across TCGA patient cohorts, RPIA mutation is significantly associated with the RNA expression of many other genes, with 2,462 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPIA-associated genes across cancer lineages are MIR4672, LINC01899, and AGKP1. Each is linked with RPIA in more than 1 cancer types. Because this analysis shows association rather than direction, both RPIA-to-partner and partner-to-RPIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4672 grouped by RPIA-low versus RPIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPIA→partner) and Y-score (partner→RPIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4672 →	+0.290	+1.848	.009	.009	3	2
UCEC	LINC01899 →	+0.087	+2.019	<.001	.008	3	2
SKCM	AGKP1 →	+0.071	+3.525	<.001	.002	3	2
LUSC	IL9 →	+0.206	+4.144	<.001	.004	3	2
LUSC	RNU6-1029P →	+0.526	+4.947	<.001	<.001	3	2
LUSC	LINC02559 →	+0.413	+4.279	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,462 associations by consensus.

MIR4672 by RPIA expression — UCEC

Explore this box plot interactively →