RPIA

Across TCGA patient cohorts, RPIA mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPIA-associated genes across cancer lineages are ATM, FoxM1, and Smad3. Each is linked with RPIA in more than 1 cancer types. Because this analysis shows association rather than direction, both RPIA-to-partner and partner-to-RPIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RPIA-low versus RPIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPIA→partner) and Y-score (partner→RPIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.676	-2.584	.001	.011	3	2
UCEC	FoxM1 →	+0.285	+2.584	.018	.011	3	1
UCEC	Smad3 →	+0.142	+2.321	.042	.034	3	1
UCEC	STAT3_pY705 →	-0.590	-3.700	<.001	.001	3	1
UCEC	Tuberin →	+0.346	+2.584	.005	.011	3	1
UCEC	VHL →	-1.234	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by RPIA expression — UCEC

Explore this box plot interactively →