RPIA

Across TCGA cell cohorts, RPIA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,785 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RPIA-associated GO terms across cancer lineages are Pentose-phosphate shunt, non-oxidative branch, D-ribose metabolic process, and Glyceraldehyde-3-phosphate metabolic process. Each is linked with RPIA in more than 18 cancer types. Because this analysis shows association rather than direction, both RPIA-to-partner and partner-to-RPIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pentose-phosphate shunt, non-oxidative branch grouped by RPIA-low versus RPIA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPIA→partner) and Y-score (partner→RPIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pentose-phosphate shunt, non-oxidative branch →	+0.188	+0.992	<.001	<.001	3	19
LIVER	D-ribose metabolic process →	+0.273	+1.218	<.001	.001	3	19
BONE	Glyceraldehyde-3-phosphate metabolic process →	+0.171	+0.918	<.001	<.001	3	17
PANCREAS	Pentose-phosphate shunt →	+0.128	+0.739	<.001	<.001	3	16
LUNG_SCLC	Pentose metabolic process →	+0.194	+0.724	<.001	<.001	3	15
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.110	+0.753	.004	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,785 associations by consensus.

Pentose-phosphate shunt, non-oxidative branch by RPIA expression — BONE

Explore this box plot interactively →