RPGRIP1

Across TCGA cell cohorts, RPGRIP1 mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPGRIP1-associated genes across cancer lineages are DMRTC1, DMRTC1B, and IQCF5. Each is linked with RPGRIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPGRIP1-to-partner and partner-to-RPGRIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTC1 grouped by RPGRIP1-low versus RPGRIP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPGRIP1→partner) and Y-score (partner→RPGRIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DMRTC1 →	+0.240	+4.177	<.001	.001	3	2
BLOOD_Leukemia	DMRTC1B →	+0.517	+3.971	<.001	.002	3	2
BLOOD_Leukemia	IQCF5 →	+0.072	+4.201	<.001	.001	3	2
LARGE_INTESTINE	EYA3 →	+0.634	+3.364	<.001	.002	3	2
LARGE_INTESTINE	UBR2 →	+0.697	+3.169	<.001	.009	3	2
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

DMRTC1 by RPGRIP1 expression — BLOOD_Leukemia

Explore this box plot interactively →